Spitzer Space Telescope, the fourth and final of NASA's Great Observatories, and the cornerstone to NASA's Origins Program, launched on 25 August 2003 into an Earth-trailing solar orbit to acquire infrared observations from space. Spitzer has an 85cm diameter beryllium telescope, which operates near absolute zero utilizing a liquid helium cryostat for cooling the telescope. The helium cryostat, though designed for a 2.5 year lifetime, through creative planning now has an expected lifetime of 5.5 years. Spitzer has completed its in-orbit checkout/science verification phases and the first two years of nominal operations, becoming the first mission to execute astronomical observations from a solar orbit. Spitzer was designed to probe and explore the universe in the infrared utilizing three state of the art detector arrays providing imaging, photometry, and spectroscopy over the 3-160 micron wavelength range...