The present study investigated “inhibition of return” which refers to increased response latency when the target in a location discrimination task appears in the same location on consecutive trials. Location discrimination tasks were performed by 28 university students (19–21 years of age) in two experiments. In Exp. 1 the task was to press a left or right button in response to a stimulus displayed on a computer screen. The first condition manipulated stimulus-response compatibility which resulted in changing the inhibition of return. Inhibition of return was stronger when the condition was stimulus-response incompatibility. This result shows that inhibition of return functions strongly under incompatible conditions. A second condition required performance of dual tasks in Exp. 2. Again, changes in inhibition of return were seen. These results show that inhibition of return functions strongly under both dual task and incompatible conditions. Inhibition of return was interpreted as functioning strongly when the task was more difficult.