A case study on fragments in Greek manuscript collections was conducted at the Center for History and Palaeography of the National Bank of Greece Cultural Foundation. The majority of the manuscripts for the study come from hard-to-reach monastic libraries and were microfilmed by the Center. The study focused on a selection of collections, including the library of the Monastery of Hozoviotissa (Amorgos Island, Cyclades), the Patriarchal library of Alexandria (Egypt), the library of the Monastery of Iviron (Mt. Athos), and a variety of collections from Cyprus. While research is ongoing, the current results show the potential contribution that fragments can make to the study of Medieval Greek manuscripts.