The state of South Carolina is examined by the physiographic provinces of Mountains, Piedmont, and Coastal Plain using established Paleoindian projectile point types and their geographic distributions by raw materials. Foraging ranges are reconstructed. There is a substantial drop in post-Clovis point frequencies, as seen elsewhere in the Southeast, with a great increase by Dalton times. Younger Dryas age environmental changes are reviewed, with late Pleistocene flora and fauna changes noted. Starting in Dalton times, sea level rise appears to have affected settlement strategies due to the inundation of the primary resource habitats of the Coastal Plain. The Piedmont Transhumance hypothesis is offered as an explanation of these changes.