This paper discusses possibilities for pyrethrum Chrysanthemum cinerariaefolium (Trevir.) Vis. production in southern regions of Slovakia, with an emphasis on target marketing, management constraints and further research. Pyrethrum is not a traditional crop in Slovakia but prospects have opened up for its cultivation. The high yields and quality of some suitable pyrethrum ecotypes provide the grounds for effective field production under favorable conditions. Pyrethrum yielding 1.275 t of dried flowers per hectare and having at least 1.5% pyrethrum content can be a profitable and highly lucrative crop with an economic result ranging from 413 to 1071 ? per ha. A SWOT analysis revealed that pyrethrum production in Slovakia could take a course of an offensive strategy. However, intensive production of this commodity needs further development. Prospects for this non-traditional crop in Slovakia are also promising in terms of development of farming systems in which plant protection products of botanical origin would be welcome. Improved processing and stabilization of extract would further increase the possibilities.