Green innovation and production have been used as a strategic tool to increase sustainability in response to the rising concerns regarding the adverse effect of business behaviors on environment. The sophisticated processes involved in green innovations have been attracting a great amount of attention in business field as well as in academia. Finding ways to increase green innovations is an urgent issue facing many managers. This study proposes a conceptual framework to put a company’s green innovation under the whole supply chain and identify the role of green information system in helping a company to achieve integration with its suppliers and customers and improving its green innovation thereafter. The conceptual framework is proposed and tested empirically by using the data collected from 231 companies in China. This study makes contributions to the literature in finding ways to improve green innovation and production through the management of the whole supply chain, by investigating green innovation over the whole supply chain and identify role of green information system in facilitating the process. This finding is also useful for real-world practitioners in finding practical ways to increase green innovation and production to achieve competitive advantage.