Protein digestibility and relevance to allergenicity.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2003 United Kingdom English Publisher:American Chemical Society (ACS)Journal:Environmental Health Perspectives, volume 111, pages 1,122-1,124 (issn: 0091-6765, eissn: 1552-9924,

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Authors: Bannon, Gary; Fu, Tong Jen; Kimber, Ian; Hinton, Dennis M.;

doi: 10.1289/ehp.5812

pmid: 12826484

pmc: PMC1241561

Protein digestibility and relevance to allergenicity.

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Abstract

In January 2001 a Joint Food and Agriculture Organization of the United Nations/World Health Organization Expert Consultation Committee on Allergenicity of Foods Derived from Biotechnology published a report outlining in detail an approach for assessing the allergenic potential of novel proteins. One component of this decision tree is a determination of whether the protein of interest is resistant to proteolytic digestion. Although these (Italic)in vitro(/Italic) methodologies have been useful, the correlation between resistance to proteolysis and allergenic activity is not absolute. Two views and highlights of supporting research regarding the relationship of resistance to digestion and allergenicity are presented in this article.

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United Kingdom

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Keywords

Decision Trees, Food, Genetically Modified, Simulated gastric fluid, World Health Organization, Risk Assessment, Allergenicity, Proteolytic digestion, Safety assessment, Protein stability, Sequence homology, Protein structure, Humans, Dietary Proteins, Public Health, Food Hypersensitivity, Peptide Hydrolases

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