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Fibrin and D-dimer bind to monomeric GPVI

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 15 Aug 2017 English Publisher:American Society of HematologyJournal:Blood Advances, volume 1, pages 1,495-1,504 (issn: 2473-9529, eissn: 2473-9537, Copyright policy )
Authors: Marie-Blanche Onselaer; Alexander T. Hardy; Clare Wilson; Ximena Sanchez; Amir K. Babar; Jeanette L. C. Miller; Callum N. Watson; +7 Authors

doi: 10.1182/bloodadvances.2017007732

pmid: 29296791

pmc: PMC5728468

Fibrin and D-dimer bind to monomeric GPVI

Abstract

Key Points GPVI is the major signaling receptor for fibrin in human platelets; the GPVI binding site is located in the fibrin D-dimer region. D-dimer blocks platelet aggregation by fibrin and collagen but not by a collagen-related peptide, suggesting a distinct binding epitope.

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Keywords

RC581-951, Specialties of internal medicine

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 77
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
77
Top 10%
Top 10%
Top 1%
Green
gold
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