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University of Birmingham

University of Birmingham

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3,876 Projects, page 1 of 776
  • Funder: UK Research and Innovation Project Code: 1916027

    My thesis will offer the first in-depth study of the relation between photography and philosophical thought in Woolf's fiction. Responding to a new critical appreciation of the ways in which Woolf's experimentation with photography shaped her literary aesthetics and contributed the ubiquitous descriptions of photographs and portraits in her novels, my thesis will offer an alternative interpretation of her literary engagement with photography. Rather than focusing on literal descriptions of photographs in Woolf's fiction, I propose that the mapping of photographic metaphors onto depictions of the city reflects a desire to interrogate her philosophical relation to the world and test the limits of identity.

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  • Funder: UK Research and Innovation Project Code: EP/R512436/1
    Funder Contribution: 1,541,910 GBP

    Doctoral Training Partnerships: a range of postgraduate training is funded by the Research Councils. For information on current funding routes, see the common terminology at https://www.ukri.org/apply-for-funding/how-we-fund-studentships/. Training grants may be to one organisation or to a consortia of research organisations. This portal will show the lead organisation only.

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  • Funder: UK Research and Innovation Project Code: G0700301
    Funder Contribution: 347,503 GBP

    Most liver diseases occur as a consequence of uncontrolled inflammation mediated by white blood cells recruited into the liver from the blood. White blood cells enter the liver via channels or sinusoids that are lined by specialised cells called endothelial cells which the white cells must bind to and migrate between before they can enter liver tissue. We propose that this process will a) determine the nature of the cells recruited and b) determine how those cells become activated and thereby the outcome of liver injury. We have developed complex test tube models in which combinations of human liver cells are grown under particular conditions that mimic the environment within the diseased liver sinusoids. We will use these models to investigate how white cells are recruited and how interactions with sinusoidal cells can define the activation status of the cells during their recruitment. Understanding this process will elucidate why in some circumstances white blood cells can promote the repair of the damaged liver whereas in other circumstances they amplify liver injury. We hope to use this information to develop new therapies to manipulate white blood cells in the liver in favour of repair rather than continuing liver damage and thereby to reverse inflammatory liver disease and prevent liver cirrhosis.

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  • Funder: European Commission Project Code: 796487
    Overall Budget: 183,455 EURFunder Contribution: 183,455 EUR

    COINE will provide the first comprehensive history of counterfeiting as an imperial crime, demonstrating that it had wide-ranging implications for market development, cultures of money and the market, and imperial authority in the eighteenth-century British Atlantic world. Combining methods from social, cultural, and political history with analysis of material and visual culture, COINE engages with interdisciplinary issues, including the dynamics between crime and economic development; the relationship of money to the state; and the evolution of money in the modern world. To accomplish COINE’s objectives, the Experienced Researcher (ER) will complete six months of field work in British archives, collecting data on British-based counterfeiting networks which will be assembled into a relational database and integrated into the ER’s existing database on counterfeiters operating in the British colonies. This data will allow the ER to accurately trace, for the first time, the movements of counterfeiters and their extensive networks in the British Atlantic world. Based at University of Birmingham (UoB) and benefiting from the expertise of the Supervisor and the Birmingham Eighteenth-Century Center, the ER will produce a monograph, Counterfeiting Empire, on money, crime, and politics in the eighteenth century. The results will also be disseminated in a single-authored article and conference presentations. COINE is thus designed to allow the ER to access critical archives, complete data analysis and writing that will be enriched by the intellectual community at UoB, and disseminate results that will change how scholars think about crime, money, and imperial politics. The ER will bring her expertise on the emerging field of the history of money to the UoB and help the institution strengthen ties with American researchers. COINE’s work programme will also augment the ER’s international research profile and position to obtain a permanent academic position.

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  • Funder: European Commission Project Code: 840567
    Overall Budget: 277,940 EURFunder Contribution: 277,940 EUR

    Vitamin D has well-recognised actions on the skeleton, but also exerts potent effects on extra-skeletal tissues. Current approaches to measure vitamin D almost exclusively rely on measuring a single, inactive vitamin D metabolite – 25-hydroxyvitamin D. However, vitamin D undergoes complex metabolism that may strongly influence the physiological impact of vitamin D. This is particularly important for extra-skeletal responses to vitamin D, where tissue-specific metabolites appear to be a crucial component of vitamin D activity. Hence, to better understand the broader role of vitamin D in human health there is an urgent need for new analytical methods that more accurately define optimal levels of vitamin D. The current project will develop state-of-the-art mass spectrometry methods for more comprehensive measurement of vitamin D metabolism in blood and solid tissues. Studies during the outgoing phase of the project will establish more comprehensive LC-MS/MS methods for analysis of classical vitamin D metabolism pathways, as well as alternative metabolic pathways. LC-MS/MS methods will also be developed to measure polymorphic variants of the serum vitamin D binding protein, and thereby enable clearer definition of the bioavailability of vitamin D metabolites. These new methods will initially be validated using a large human cohort at the outgoing phase. Finally, novel MALDI mass spectrometry imaging methods will be developed to visualise vitamin D metabolites in solid tissues. Translational application of each new analytical method will be tested on the return phase of the project through studies of large patient cohorts with both serum and tissue samples (placenta and skin tissues). Further enhancement of analytical methods will be achieved through an industrial secondment that will provide access to cutting-edge equipment. The project will establish an entirely new philosophy and methodology for the measurement of vitamin D biomarkers in health and disease.

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