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Fibrin activates GPVI in human and mouse platelets

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 24 Sep 2015 English Publisher:American Society of HematologyJournal:Blood, volume 126, pages 1,601-1,608 (issn: 0006-4971, eissn: 1528-0020,

Authors: Jonathan Frampton; Markus Bender; Craig E. Hughes; Stephanie Watson; Steve P. Watson; Osama Alshehri; Samantha J. Montague;

doi: 10.1182/blood-2015-04-641654

pmid: 26282541

pmc: PMC4582337

Fibrin activates GPVI in human and mouse platelets

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Abstract

Key PointsFibrin is a novel ligand for the platelet collagen receptor, GPVI, increasing platelet procoagulant activity. Activation of GPVI by fibrin contributes to thrombus growth and stabilization.

Related Organizations

University of Birmingham
United Kingdom
University of Würzburg
Germany

Keywords

Blood Platelets, Fibrin, Mice, Animals, Humans, Thrombosis, Platelet Membrane Glycoproteins, Phosphorylation, Blood Coagulation

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	204
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%