Progressive supranuclear palsy

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Dec 2001 English Publisher:BMJJournal:Molecular Pathology, volume 54, pages 427-434 (issn: 1366-8714, eissn: 1472-4154,

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Authors: K, Tawana; D B, Ramsden;

doi: 10.1136/mp.54.6.427

pmid: 11724919

pmc: PMC1187134

Progressive supranuclear palsy

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Abstract

This review concentrates on the molecular pathology of the protein tau, including its expression in various regions of the brain. The role of post-translational modifications in fibrillogenesis is also discussed, particularly hyperphosphorylation and glycation. However, the initiating event that causes aberrant tau processing remains unclear.

Related Organizations

University of Birmingham
United Kingdom
University Hospitals Birmingham NHS Foundation Trust
United Kingdom
Queen Elizabeth Hospital Birmingham
United Kingdom

Keywords

Neurons, Polymorphism, Genetic, Cell Death, Brain, Neurofibrillary Tangles, tau Proteins, Microtubules, Oxidative Stress, Humans, Protein Isoforms, Supranuclear Palsy, Progressive

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