Active cortical dendrites modulate perception
Copyright policy )Active cortical dendrites modulate perception
Now you feel it, now you don't What determines the detection of a sensory stimulus? To address this question, Takahashi et al. combined in vivo two-photon imaging, electrophysiology, optogenetics, and behavioral analysis in a study of mice. Calcium signals in apical dendrites of pyramidal neurons in the somatosensory cortex controlled the perceptual threshold of the mice's whiskers. Strong reduction of dendritic calcium signaling impaired the perceptual detection threshold so that an identical stimulus could no longer be noticed. Science , this issue p. 1587
- University Medical Center Hamburg-Eppendorf Germany
- Humboldt-Universität zu Berlin Germany
- Universität Hamburg Germany
Pyramidal Cells, Dendrites, Somatosensory Cortex, Mice, Inbred C57BL, Mice, Discrimination, Psychological, Sensory Thresholds, Vibrissae, Animals, Calcium, Calcium Signaling
Pyramidal Cells, Dendrites, Somatosensory Cortex, Mice, Inbred C57BL, Mice, Discrimination, Psychological, Sensory Thresholds, Vibrissae, Animals, Calcium, Calcium Signaling
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