AbstractBackgroundSkin topographic measurements are of paramount importance in the field of dermo‐cosmetic evaluation. The aim of this study was to investigate how the Antera 3D, a multi‐purpose handheld camera, correlates with other topographic techniques and changes in skin topography following the use of a cosmetic product.MethodsSkin topographic measurements were collected on 26 female volunteers aged 45‐70 years with the Antera 3D, the DermaTOP and image analysis on parallel‐polarized pictures. Different filters for analysis from the Antera 3D were investigated for repeatability, correlations with other imaging techniques and ability to detect improvements of skin topography following application of a serum.ResultsMost of Antera 3D parameters were found to be strongly correlated with the DermaTOP parameters. No association was found between the Antera 3D parameters and measurements on parallel‐polarized photographs. The measurements repeatability was comparable among the different filters for analysis, with the exception of wrinkle max depth and roughness Rt. Following a single application of a tightening serum, both Antera 3D wrinkles and texture parameters were able to record significant improvements, with the best improvements observed with the large filter.ConclusionThe Antera 3D demonstrated its relevance for cosmetic product evaluation. We also provide recommendations for the analysis based on our findings.