Abstract The conservation of the vulnerable Asiatic black bear ( Ursus thibetanus ) in Pakistan is challenged by retaliatory killing, driven by negative interactions between people and bears, such as livestock depredation. We distributed a questionnaire among 369 individuals in rural communities within the Mansehra District, Pakistan, where bear retaliatory killings are often reported. We focused on human–Asiatic black bear negative interactions, such as livestock depredations, crop damage, and human injuries occurring between 2015 and 2019. Although the number of livestock depredation events was small in absolute terms (an average of 11.5 livestock heads reported to be killed annually), it had a large estimated economic impact in terms of local economies ($1367 per year, or a total of $5.469 between 2015 and 2019). Such annual estimated costs account for 93% of the per capita gross domestic product for Pakistan, roughly equivalent to $55,853 for a US citizen. Additionally, 30 incidents between people and bears were registered, where 6% human were fatal. We recommend awareness campaigns on different mitigating interventions, and training on how to use them, as well as behaviors to reduce the risk of negative interactions.