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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao British Journal of U...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
British Journal of Urology
Article . 2015 . Peer-reviewed
License: Wiley Online Library User Agreement
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Telemetric monitoring of bladder function in female Göttingen minipigs

Authors: Nadine D, Huppertz; Ruth, Kirschner-Hermanns; Rene H, Tolba; Joachim O, Grosse;

Telemetric monitoring of bladder function in female Göttingen minipigs

Abstract

Objectives To generate real‐time radio‐telemetric urodynamic reference data of maximum detrusor pressure ( P det max ), maximum flow rate ( Q max) and estimated grade of infravesical obstruction, as well as duration of detrusor contraction ( DOC ), in female Göttingen minipigs and to describe translational aspects of the use of Göttingen minipigs for urological research. Materials and Methods A telemetric transmitter was implanted into five female Göttingen minipigs, and 24 h measurements in metabolic cages were taken. Through operator‐based analysis, synchronized real‐time radio‐telemetric cystometric data with flowmetric data and video sequences were used to determine voiding detrusor contractions ( VC s) and non‐voiding detrusor contractions ( NVC s). Furthermore, data from telemetric natural‐filling cystometry from free‐moving and restricted maintenance conditions were compared for potential differences. Results The median (range) P det max of VC s was 120.6 (21.0–370.0) cmH 2 O and, therefore, significantly different from that of NVC s (64.60 [20.4–280.6 cmH 2 O] cm H 2 O). Intraindividual comparison of minipig data revealed great differences in voiding contractions. The effects of limited movement on VC s were analysed and showed significantly higher P det max and lower DOC than in free‐moving conditions. Conclusion The presented data can be used for the development of telecystometric implanted minipig models, to investigate changes of detrusor function such as under‐ or overactivity, and might serve as model for bladder changes occurring with iatrogenic bladder outlet obstruction ( BOO ) or different therapeutic options for overactive bladder. Radio‐telemetric real‐time natural filling and voiding cystometries are feasible, reproducible in non‐anaesthetized minipigs with free or limited movement and can give new insights into circadian behaviour and physiological and pathological bladder function.

Related Organizations
Keywords

Swine, Urinary Bladder, Diagnostic Techniques, Urological, Equipment Design, Urinary Bladder Neck Obstruction, Disease Models, Animal, Urodynamics, Animals, Swine, Miniature, Telemetry, Female, Muscle Contraction

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
11
Top 10%
Average
Average
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