Crop growth is greatly affected by light intensity, temperature and CO 2 concentration. The combinations of these factors are considered in growing crops. In this study, a system was developed using adaptive neuro-fuzzy inference system for the prediction of the photosynthetic rate of lettuce crop based on the temperature, light intensity and CO 2 . A fuzzy inference system is designed to generate the rules for the fuzzy logic where inputs of these are from the output of the trained neural network. Based on the result, the system was able to predict the photosynthetic rate of the lettuce crop based on the three input parameters. The RMSE value for the ANFIS model was found to be 2.7843e-05.