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Acta Crystallographica Section D Biological Crystallography
Article . 2015 . Peer-reviewed
License: CC BY
Data sources: Crossref
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FEM: feature-enhanced map

Authors: Dušan Turk; Alexandre Urzhumtsev; Alexandre Urzhumtsev; Pavel V. Afonine; Oleg V. Sobolev; Paul D. Adams; Paul D. Adams; +3 Authors
Abstract

A method is presented that modifies a 2mFobs−DFmodelσA-weighted map such that the resulting map can strengthen a weak signal, if present, and can reduce model bias and noise. The method consists of first randomizing the starting map and filling in missing reflections using multiple methods. This is followed by restricting the map to regions with convincing density and the application of sharpening. The final map is then created by combining a series of histogram-equalized intermediate maps. In the test cases shown, the maps produced in this way are found to have increased interpretability and decreased model bias compared with the starting 2mFobs−DFmodelσA-weighted map.

Keywords

Models, Molecular, FEM, Fourier map, map improvement, map kurtosis, OMIT, map sharpening, Biophysics, Molecular, PHENIX, Biological Sciences, density modification, model bias, Research Papers, cctbx, Models, Physical Sciences, Chemical Sciences, feature-enhanced map

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    158
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
158
Top 1%
Top 10%
Top 1%
Green
hybrid