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Clinical Chemistry
Article . 2000 . Peer-reviewed
License: OUP Standard Publication Reuse
Data sources: Crossref
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Clinical Chemistry
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Point-of-Care Testing of Triglycerides: Evaluation of the Accutrend Triglycerides System

Evaluation of the accutrend triglycerides system
Authors: Stephan J. L. Bakker; Andrew Hattemer; Hans-Detlev Gottschling; Valerie Paal; Sabine Westphal; Gunnar Ronquist; Reuter W; +3 Authors

Point-of-Care Testing of Triglycerides: Evaluation of the Accutrend Triglycerides System

Abstract

The importance of triglycerides in the development of atherosclerosis is currently receiving increasing attention in view of the growing evidence that triglycerides constitute an independent risk factor for cardiovascular disease (1). The atherogenicity of hypertriglyceridemia is particularly apparent not only in fully developed type 2 diabetes mellitus, but also in individuals with a complete or incomplete metabolic syndrome. The four prominent symptoms of the latter (hypertriglyceridemia, abdominal obesity, insulin resistance, and hypertension) have even been named “the deadly quartet” (2). The pathological processes linking triglyceride-rich lipoproteins with the appearance and growth of atheromas are complex. Triglyceride-rich lipoproteins themselves may be involved, or their remnant products, or low concentrations of HDL-cholesterol, which are most frequently found in association with hypertriglyceridemia (3). Not only fasting triglycerides have been shown to be associated with atherosclerosis (4)(5)(6), but also postprandial triglycerides, which can reach remarkably high concentrations (4). Glucose is a regularly controlled variable in patients suffering from diabetes mellitus or the metabolic syndrome. Glucose testing is performed not only in doctors’ offices but also by the patients at home, using glucose-specific point-of-care testing devices. In contrast, triglycerides, which similarly to glucose exhibit a considerable variation throughout the day that is related mainly to food intake, could not be monitored in this way because of a lack of corresponding point-of-care testing instrumentation. The development of such a device for rapid point-of-care triglyceride measurement, therefore, appeared advantageous, allowing as it does rapid monitoring of triglycerides by both doctors and patients. Although no cutpoints at which postprandial triglycerides increase the risk of cardiovascular disease are defined at present, information about a patient’s metabolic status with respect to triglycerides throughout the day and use of this information to reduce triglyceride concentrations throughout the day may serve as a further step toward reducing …

Country
Netherlands
Keywords

Diabetes Mellitus, Type 2, CORONARY-ARTERY DISEASE, Point-of-Care Systems, Humans, METABOLISM, Triglycerides

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
52
Top 10%
Top 10%
Top 10%
hybrid