Tame affairs: domesticated transposase and domestic pigs

descriptionPublicationkeyboard_double_arrow_right Article 26 Feb 2010 English Publisher:Springer Science and Business Media LLCJournal:EMBO reports, volume 11, pages 241-242 (issn: 1469-221X, eissn: 1469-3178,

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Authors: Jean-Nicolas, Volff;

doi: 10.1038/embor.2010.31

pmid: 20203696

pmc: PMC2854596

Tame affairs: domesticated transposase and domestic pigs

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Abstract

Long thought to be genomic junk, domesticated transposons have turned out to be an incredible source of new genes. Two studies—one this issue of EMBO reports—show that a domesticated hAT transposase is a transcriptional repressor of IGF2 that regulates muscle growth and has over 1,200 additional putative targets in the mammalian genome.

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Keywords

Evolution, Molecular, Swine, Sus scrofa, DNA Transposable Elements, Animals, Transposases, Models, Biological

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