Abstract The aim of this research is to propose an urban logistics distribution service which benefits from the already installed passenger transport network. This service is based upon the concept of integration of the existing passenger transport network with the urban freight process. The aim is to reduce the number of fossil combustion powered commercial vehicles traveling within city boundaries, solely for goods transportation, thus contributing to reduce negative effects of urban logistics activities, namely pollution, noise, traffic congestion and accidents. Also, integrating goods and passenger flows will promote higher efficiency rates for the passenger transport network and enhance living conditions within major urban centers. A mathematical model for the operational planning of the proposed urban logistics distribution service is proposed. This model consists of assigning origins loads (or requests) to inbound hubs (bus operator centers), transferring the inbound hubs loads to a bus service, and transferring the bus loads to bus stops, to be collected by micro-logistics operators operating environmentally friendly vehicle fleets. The objective is to minimize the total service time while assuring services synchronization along the network and balancing the loads with the system capacities.