The aim of this study was to examine the prevalence of signs and symptoms of temporomandibular joint (TMJ) dysfunction in persons with Marfan syndrome.A questionnaire was distributed to 350 patients with Marfan syndrome. Twenty-one patients were additionally subjected to a clinical examination and magnetic resonance imaging (MRI) of the TMJ.The prevalence of symptoms of TMJ dysfunction was 51.6% (n=145), with 24.2 % (n=68) indicating symptoms of subluxation, and 34.9% (n=98) of the patients already undergoing medical treatment for their TMJ problems. Anterior disc displacement with and without reduction was observed in 17 of the examined patients (81.0%), with 4 of these patients additionally showing osteoarthrosis of the affected temporomandibular joints.TMJ dysfunction appears to be an important aspect in Marfan syndrome.