DUX4 Pathological Expression: Causes and Consequences in Cancer
Copyright policy )DUX4 Pathological Expression: Causes and Consequences in Cancer
DUX4, a double homeobox transcription factor, has been mostly studied in facioscapulohumeral dystrophy (FSHD), a pathology linked to a deletion of subtelomeric repeats on chromosome 4q. More recently, however, the gene has been associated with various sarcomas and haematological malignancies. Drugs developed for FSHD could be tested on cancer cells to develop efficient treatment strategies for both pathologies.
- Institut Gustave Roussy France
- Koltzov Institute of Developmental Biology Russian Federation
- Department of Biological Sciences Russian Federation
- French National Centre for Scientific Research France
- University of Paris-Saclay France
Gene Rearrangement, Homeodomain Proteins, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Neoplasms, Humans, Protein Interaction Domains and Motifs, Disease Susceptibility, Molecular Targeted Therapy, Protein Binding
Gene Rearrangement, Homeodomain Proteins, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Neoplasms, Humans, Protein Interaction Domains and Motifs, Disease Susceptibility, Molecular Targeted Therapy, Protein Binding
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