Abstract The maize weevil, Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae), is one of the major pests of maize worldwide. We tested one Tripsacorn-introgressed inbred maize line and 42 hybrid combinations between eleven public inbred lines and 16 different Tripsacorn-introgressed inbreds for resistance to the maize weevil to investigate if there is a genetic basis for resistance to the maize weevil that can be conferred to maize. No progeny were produced in 21 of the entries, and only eight entries had progeny production significantly greater than zero. All the lines that exhibited complete resistance (no progeny produced) are F 1 hybrids between 10 different Tripsacorn-introgressed inbred lines combined with 8 different public maize inbreds. Results indicate that all 16 Tripsacorn-introgressed inbred lines confer resistance in F 1 hybrids. In some of the Tripsacorn-introgressed lines, the degree of resistance expressed varied according to combining ability and heterotic group background. Based on the results, we hypothesize a dominant gene for weevil resistance is inherited from Tripsacorn. The data indicate that Tripsacorn provides a valuable tool for conferring native weevil resistance to maize.