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Food and Chemical Toxicology
Article . 2015 . Peer-reviewed
License: CC BY NC ND
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Food and Chemical Toxicology
Article
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Food and Chemical Toxicology
Article . 2015
License: CC BY NC ND
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Dietary exposure to volatile and non-volatile N-nitrosamines from processed meat products in Denmark

Authors: Herrmann, Susan Strange; id_orcid 0000-0001-6871-8527; Duedahl-Olesen, Lene; id_orcid 0000-0002-3162-0101; Christensen, Tue; id_orcid 0000-0001-7693-7359; Olesen, Pelle Thonning; id_orcid 0000-0001-8290-3374; Granby, Kit; id_orcid 0000-0002-5264-1577;

Dietary exposure to volatile and non-volatile N-nitrosamines from processed meat products in Denmark

Abstract

Recent epidemiological studies show a positive association between cancer incidence and high intake of processed meat. N-nitrosamines (NAs) in these products have been suggested as one potential causative factor. Most volatile NAs (VNAs) are classified as probable human carcinogens, whereas the carcinogenicity for the majority of the non-volatile NA (NVNA) remains to be elucidated. Danish adults (15-75 years) and children (4-6 years) consume 20 g and 16 g of processed meat per day (95th percentile), respectively. The consumption is primarily accounted for by sausages, salami, pork flank (spiced and boiled) and ham. This consumption results in an exposure to NVNA of 33 and 90 ng kg bw(-1) day(-1) for adults and children, respectively. The exposure to VNA is significantly lower amounting to 0.34 and 1.1 ng kg bw(-1) day(-1) for adults and children, respectively. Based on a BMDL10 of 29 µg kg bw(-1) day(-1) a MOE value ≥17,000 was derived for the exposure to NA known to be carcinogenic (VNA including NSAR), indicating an exposure of low concern. The exposure to the NVNA is substantially higher and if found to be of toxicological significance the exposure may be of concern.

Country
Denmark
Related Organizations
Keywords

Adult, Nitrosamines, Adolescent, Nitrite curing, Denmark, Food Contamination, Toxicology, Dietary exposure, Young Adult, Risk Factors, Animals, Humans, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being, Child, Risk assessment, Aged, Volatile Organic Compounds, N-nitroso compounds, Middle Aged, Diet, Meat Products, Child, Preschool, Food Science

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
76
Top 1%
Top 10%
Top 10%
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