Abstract A growing body of research has documented the development of pervasive anti-Muslim sentiment among White Americans. We build on this research to demonstrate that anti-Muslim attitudes and negative stereotypes of Muslim people have become an enduring and consistent component of White Americans' presidential vote choice beyond any one specific candidate or election. We argue that the racialization of Muslim Americas has increased their salience and significance in both the minds of White Americans and in national political discourse, making attitudes toward Muslims a consistent predictor of Whites’ presidential candidate evaluations in every election since at least 2004. We support this account with empirical evidence from the 2004–2020 American National Election Studies, using measures of group affect and negative stereotypes of Muslim people.