Splines, model selection, penalization, Variable selection, interpretable models, Model selection, supervised learning, Applications of statistics to biology and medical sciences; meta analysis, splines, Nonparametric regression and quantile regression, function estimation, lasso, [MATH.MATH-ST] Mathematics [math]/Statistics [math.ST], Interpretable models, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Computational problems in statistics, Function estimation, smoothing, Nonparametric regression, [INFO.INFO-LG] Computer Science [cs]/Machine Learning [cs.LG], nonparametric regression, Lasso, Supervised learning, Penalization, Smoothing, variable selection