Common TLR5 Mutations Control Cancer Progression
Copyright policy )Common TLR5 Mutations Control Cancer Progression
The mechanisms regulating tumor-associated inflammation are incompletely understood. In this issue of Cancer Cell, Rutkowski and colleagues indicate that TLR5 signaling deficiency, which occurs in ∼10% of the population, changes interactions with commensal microbiota and deregulates a cascade of inflammatory events that can suppress or accelerate extraintestinal cancers.
- University of Geneva Switzerland
- Center for Systems Biology United States
- Harvard University United States
Cancer Research, Neoplasms/immunology/pathology, Interleukin-6, Microbiota, Interleukin-6/metabolism, Interleukin-17, Cell Biology, Toll-Like Receptor 5, Interleukin-17/metabolism, Oncology, Neoplasms, Toll-Like Receptor 5/genetics/metabolism, Animals, Humans
Cancer Research, Neoplasms/immunology/pathology, Interleukin-6, Microbiota, Interleukin-6/metabolism, Interleukin-17, Cell Biology, Toll-Like Receptor 5, Interleukin-17/metabolism, Oncology, Neoplasms, Toll-Like Receptor 5/genetics/metabolism, Animals, Humans
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