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Does Weight Impact Anidulafungin Pharmacokinetics?

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 03 May 2016 Netherlands, Netherlands English Publisher:Springer Science and Business Media LLCJournal:Clinical Pharmacokinetics, volume 55, pages 1,289-1,294 (issn: 0312-5963, eissn: 1179-1926,

Authors: Lempers, V.J.; Rongen, A. van; Dongen, E.P. van; Ramshorst, B. van; Burger, D.M.; Aarnoutse, R.E.; Knibbe, C.A.J.; +1 Authors

doi: 10.1007/s40262-016-0401-8

pmid: 27142114

pmc: PMC5021753

handle: https://repository.ubn.ru.nl/handle/2066/172336 , 2066/172336 , 1887/45345

Does Weight Impact Anidulafungin Pharmacokinetics?

- Summary
- Subjects
- Metrics

Abstract

Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m(2)). Anidulafungin exposure was on average 32.5 % lower compared with the general patient population, suggesting dose increases may be required in this population.

Countries

Netherlands, Netherlands

Related Organizations

Radboud University Nijmegen
Netherlands
Leiden University
Netherlands
Leiden University
Netherlands
Leiden University
Netherlands
Radboud University Nijmegen Medical Centre
Netherlands

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Keywords

Pharmacology, Adult, Male, Antifungal Agents, Metabolic Clearance Rate, Short Communication, Middle Aged, Anidulafungin, Body Mass Index, Obesity, Morbid, Echinocandins, Area Under Curve, Humans, Pharmacology (medical), Female, Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences, Aged

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	19
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%