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Investigations of the Production of Cephalosporin C by Acremonium chrysogenum

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 17 Dec 2003Publisher:Springer Berlin Heidelberg

Authors: Karl Schügerl; M Beyer; C Tollnick; G Seidel;

doi: 10.1007/b12439

pmid: 15088762

Investigations of the Production of Cephalosporin C by Acremonium chrysogenum

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Abstract

A review is given on the morphology of Acremonium chrysogenum and the biosynthesis of cephalosporin C based on the published references. Investigations are presented on the comparison of cultivation media carried out by means of shake flask cultures. The process performance of a standard cultivation in well controlled bioreactor is presented and compared with other cultivations, which were executed with the same strain and bioreactor, but with various carbon-, nitrogen- and sulphur-sources keeping the concentrations of the key components at definite levels. Also the influence of dilution and enrichment of the medium on the process performance is explored. Mathematical models for the growth of Acremonium chrysogenum and production of cephalosporin C are reviewed and their application for control of industrial processes with complex cultivation media are discussed.

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Keywords

Acremonium, Bioreactors, Cell Culture Techniques, Models, Biological, Cell Division, Anti-Bacterial Agents, Cephalosporins

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	20
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average