Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 2017 English Publisher:Springer International Publishing

Authors: Martin, Lee; Kevin, Rey; Katrina, Besler; Christine, Wang; Jonathan, Choy;

doi: 10.1007/978-3-319-54090-0_8

pmid: 28455710

Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase

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Abstract

Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses. In macrophages, nitric oxide is produced by inducible nitric oxide synthase upon microbial and cytokine stimulation. It is needed for host defense against pathogens and for immune regulation. This review will summarize the role of NO and iNOS in inflammatory and immune responses and will discuss the regulatory mechanisms that control inducible nitric oxide synthase expression and activity.

Related Organizations

Simon Fraser University
Canada

Keywords

Animals, Humans, Nitric Oxide Synthase Type II, Nitric Oxide

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