Quasispecies on Fitness Landscapes
Quasispecies on Fitness Landscapes
Selection-mutation dynamics is studied as adaptation and neutral drift on abstract fitness landscapes. Various models of fitness landscapes are introduced and analyzed with respect to the stationary mutant distributions adopted by populations upon them. The concept of quasispecies is introduced, and the error threshold phenomenon is analyzed. Complex fitness landscapes with large scatter of fitness values are shown to sustain error thresholds. The phenomenological theory of the quasispecies introduced in 1971 by Eigen is compared to approximation-free numerical computations. The concept of strong quasispecies understood as mutant distributions, which are especially stable against changes in mutations rates, is presented. The role of fitness neutral genotypes in quasispecies is discussed.
- University of Vienna Austria
- Santa Fe Institute United States
SPIN-GLASSES, ERROR THRESHOLDS, STOCHASTIC SIMULATION, 106002 Biochemie, RNA SECONDARY STRUCTURES, Evolution, Molecular, 301902 Immunologie, EIGEN EVOLUTION MODEL, NATURAL SELF-ORGANIZATION, 106022 Mikrobiologie, Models, Genetic, 106002 Biochemistry, MUTATION-SELECTION MODELS, Biodiversity, MOLECULAR EVOLUTION, STATISTICAL-MECHANICS, NEUTRAL NETWORKS, Mutation, Viruses, 106022 Microbiology, Nucleic Acid Conformation, RNA, 301902 Immunology
SPIN-GLASSES, ERROR THRESHOLDS, STOCHASTIC SIMULATION, 106002 Biochemie, RNA SECONDARY STRUCTURES, Evolution, Molecular, 301902 Immunologie, EIGEN EVOLUTION MODEL, NATURAL SELF-ORGANIZATION, 106022 Mikrobiologie, Models, Genetic, 106002 Biochemistry, MUTATION-SELECTION MODELS, Biodiversity, MOLECULAR EVOLUTION, STATISTICAL-MECHANICS, NEUTRAL NETWORKS, Mutation, Viruses, 106022 Microbiology, Nucleic Acid Conformation, RNA, 301902 Immunology
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