Regulatory T Cells in Obesity

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 2015 Poland English Publisher:Springer International Publishing

Authors: Anna Małgorzata Kucharska; Beata Ewa Pyrżak; Urszula Anna Demkow;

doi: 10.1007/5584_2015_147

pmid: 26022902

Regulatory T Cells in Obesity

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Abstract

The current concept of the pathogenesis of obesity relates to the inflammation caused by excess of adipose tissue. Regulatory T cells accumulated in visceral adipose tissue (VAT-resident Tregs) are also involved in this pathogenesis. In the present paper the mechanisms responsible for alterations in the number and function of VAT-resident Tregs T in obesity are described. The role of Tregs in inflammation, insulin resistance, atherogenesis, and also the influence on VAT-resident Tregs of adipocytokines and insulin are reviewed.

Country

Poland

Related Organizations

Wrocław Medical University
Poland
Medical University of Warsaw
Poland

Keywords

Leptin, Animals, Humans, Adiponectin, Obesity, Intra-Abdominal Fat, T-Lymphocytes, Regulatory

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