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Perfect Sorting by Reversals

Authors: Sagot, Marie-France; Tannier, Eric;

Perfect Sorting by Reversals

Abstract

In computational biology, gene order data is often modelled as signed permutations. A classical problem in genome comparison is to detect conserved segments in a permutation, that is, genes that are co-localised in several species, indicating that they remained grouped during evolution. A second largely studied problem related to gene order data is to compute a minimum scenario of reversals that transforms a signed permutation into another. Several studies began to mix the two problems, and it was observed that their results are not always compatible : often parsimonious scenarios of reversals break conserved segments. In a recent study, Bérard, Bergeron and Chauve stated as an open question whether it was possible to design a polynomial time algorithm to decide if there exists a minimum scenario of reversals that transforms a genome into another while keeping the clusters of co-localised genes together. In this paper, we give this polynomial algorithm, and thus generalise the theoretical result of the aforementioned paper.

Country
France
Keywords

[INFO.INFO-OH] Computer Science [cs]/Other [cs.OH], [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], REVERSAL SORTING, GENOME REARRANGEMENTS, COMMON INTERVALS, CONSERVED SEGMENTS, COMPUTATIONAL BIOLOGY

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
6
Average
Average
Average
Green