Adaptive biased-coin designs for skewing the allocation proportion in clinical trials with normal responses

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2005 English Publisher:WileyJournal:Statistics in Medicine, volume 24, pages 2,477-2,492 (issn: 0277-6715, eissn: 1097-0258,

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Authors: A C, Atkinson; A, Biswas;

doi: 10.1002/sim.2124

pmid: 16007571

Adaptive biased-coin designs for skewing the allocation proportion in clinical trials with normal responses

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Abstract

Response adaptive designs are used in phase III clinical trial for skewing the allocation pattern towards the better treatments. We use optimum design theory to derive adaptive designs when the responses are normally distributed. The performance of the designs is studied with respect to the loss and the proportion of allocation to different treatments. The adaptive design does not affect inference.

Related Organizations

London School of Economics and Political Science
United Kingdom
Indian Statistical Institute
India

Keywords

Models, Statistical, Clinical Trials, Phase III as Topic, Research Design, Humans, Randomized Controlled Trials as Topic

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