The evolution of weed resistance to herbicides is an ever‐increasing problem that affects crop yield and food production. In Syngenta, we believe that this difficult and complex issue can be most efficiently addressed through a deep understanding of the evolutionary dynamics and mechanism of resistance. A profound knowledge of resistance is key to developing the next generation of resistance‐breaking compounds with existing or novel herbicide sites of action. We use a multidisciplinary laboratory‐based, glasshouse and field biology approach to study herbicide resistance and provide strong science‐based solutions to delay the onset and manage resistance. We have developed and implemented simple early‐season resistance detection methods to allow farmers make an informed decision for effective weed control. We have built mechanistic, individual‐based computer models to design profitable, long‐term sustainable weed management programs. Our zero tolerance approaches employ herbicides with different sites of action, applied in mixtures and sequences, to minimise the risk of resistance evolution. Weeds are targeted at the right growth stage with optimal herbicide formulation and spray technology for maximising weed control and depleting the seed bank. We are promoting the use of competitive crop varieties and other nonchemical methods for an integrated weed management strategy. We have a global web of external collaborations for studying and managing herbicide resistance. We are committed to farmers' education and training on herbicide resistance, and regularly share our methods and findings via conferences and peer‐reviewed scientific publications for the benefit of the wider weed science community and field practitioners. © 2020 Society of Chemical Industry