AbstractRust and downy mildew (DM) are detrimental diseases in global sunflower (Helianthus annuus L.) production. Disease often results in yield loss and reduced seed quality. Host resistance to DM and rust is mediated by single dominant genes in sunflower. To better utilize genetic resistance, gene pyramiding is a common practice in crop breeding to extend the durability and longevity of resistance. Two confection sunflower germplasm lines, HA‐R20 (Reg. no. GP‐387, PI 702361) and HA‐R21 (Reg. no. GP‐388, PI 702362), were developed using the pedigree breeding method and DNA marker‐assisted selection and released by the USDA‐ARS Sunflower and Plant Biology Research Unit in collaboration with the North Dakota Agricultural Experiment Station in September 2022. HA‐R20 is an F3‐derived F4 confection restorer selection from the cross of HA‐DM2 and HA‐R8, carrying rust resistance genes R12 and R15 and DM resistance gene PlArg. HA‐R21 is an F3‐derived F4 confection maintainer selection from the cross of HA‐DM3 and HA‐R8, carrying rust resistance genes R13a and R15 and DM resistance gene Pl17. Disease reaction and marker testing for DM and rust confirmed that both germplasms harbor DM and rust R genes in the homozygous condition and are resistant to all DM and rust races identified in North America to date. These multiple disease‐resistant lines will provide the sunflower industry with durable disease‐resistant sources for the continued improvement of the crop.