Abstract Understanding the ecological and human factors that shape the loss of livestock to wild carnivores can help target conservation efforts. We used 5 years of livestock depredation records (2009–2013, n = 1147) alongside Hwange National Park, Zimbabwe, to investigate how spatial patterns vary by carnivore and livestock species. Dominant patterns across all species and seasons included an increased likelihood of depredation closer to protected areas (core carnivore habitat) and in more open areas closer to human settlements (where livestock are most abundant). Lions were less likely than spotted hyenas to attack livestock further from protected areas, while goat and donkey depredation was more concentrated around homesteads compared to cattle depredation. Leopards were more likely than other predators to attack livestock in areas of higher human density and nearer water sources, likely reflecting their preference for goats and sheep which generally remain near homesteads unless taken to watering holes. Carnivores make trade‐offs between attacking livestock where it is most available (near human settlements) and where the risk of detection and retaliation by humans is lower (nearer protected areas, in more wooded habitats, and further from human activity). These results have helped target local mitigation strategies. They may also inform human–wildlife conflict mitigation at other sites globally by highlighting the need to understand species‐specific differences in conflict patterns and tailor solutions accordingly. Read the free Plain Language Summary for this article on the Journal blog.