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Proof of Concept of the Electrochemical Sensing of 3‐Iodothyronamine (T1AM) and Thyronamine (T0AM)

Authors: Gonçalves, Luís M.; Moreira, Manuela M.; Azevedo, Carla F.; Valente, Inês M.; Sousa, João Carlos; Scanlan, Thomas S.; Compton, Richard G.; +1 Authors

Proof of Concept of the Electrochemical Sensing of 3‐Iodothyronamine (T1AM) and Thyronamine (T0AM)

Abstract

AbstractRecent studies have shown that, besides the well‐recognized T3 and T4 hormones, there are other relevant thyroid hormones circulating in the human body. In particular, this is the case for 3‐iodothyronamine (T1AM) and thyronamine (T0AM). One of the reasons for the lack of studies showing their precise importance is the absence of analytical methodologies available. Herein, for the first time, T1AM and T0AM are electrochemically characterized. T0AM was sensed by means of a glassy carbon electrode; furthermore, T1AM was sensed both with a graphitic surface (oxidatively) as well as with mercury (reductively). For both compounds, after oxidation, it was possible to observe the reversible redox reaction concerning the benzoquinone/hydroquinone couple, thus increasing the specificity of the electroanalysis. Therefore, this work provides the basis for an ‘at‐point‐of‐use’ electrochemical strip test for T1AM and T0AM.

Countries
Portugal, United Kingdom
Keywords

Thyroid, Cyclic voltammetry, hormones, clinical analysis, Clinical analysis, cyclic voltammetry, Hormones, thyroid, electrochemistry, Electrochemistry

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citations
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BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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