TssA: The cap protein of the Type VI secretion system tail

descriptionPublicationkeyboard_double_arrow_right Article 17 Aug 2017 France English Publisher:WileyJournal:BioEssays, volume 39 (issn: 0265-9247, eissn: 1521-1878,

Copyright policy )Funded by:ANR | B-War, ANR | A Fun T6SS

Authors: Zoued, Abdelrahim; Durand, Eric; Santin, Yoann; Journet, Laure; Roussel, Alain; Cambillau, Christian; Cascales, E.;

doi: 10.1002/bies.201600262

pmid: 28817192

TssA: The cap protein of the Type VI secretion system tail

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Abstract

The Type VI secretion system (T6SS) is a multiprotein and mosaic apparatus that delivers protein effectors into prokaryotic or eukaryotic cells. Recent data on the enteroaggregative Escherichia coli (EAEC) T6SS have provided evidence that the TssA protein is a key component during T6SS biogenesis. The T6SS comprises a trans‐envelope complex that docks the baseplate, a cytoplasmic complex that represents the assembly platform for the tail. The T6SS tail is structurally, evolutionarily and functionally similar to the contractile tails of bacteriophages. We have shown that TssA docks to the membrane complex, recruits the baseplate complex and initiates and coordinates the polymerization of the inner tube with that of the sheath. Here, we review these recent findings, discuss the variations within TssA‐like proteins, speculate on the role of EAEC TssA in T6SS biogenesis and propose future research perspectives.

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[SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], [SDV]Life Sciences [q-bio], [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Escherichia coli, Bacteriophages, Molecular Biology, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Molecular Biology/Structural Biology [q-bio.BM], Molecular Biology/Molecular Networks [q-bio.MN], Escherichia coli Proteins, Type VI Secretion Systems, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Molecular Biology/Molecular biology, [SDV] Life Sciences [q-bio], [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, [SDV.BBM.MN] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology

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