Abstract Oceanic marine protected areas (MPAs) that are close to the litter accumulation zones in the subtropical gyres receive large amounts of plastic litter, both as micro‐ and as macroplastics. The macro‐litter accumulating on the islands in the Easter Island Ecoregion (Rapa Nui and Salas y Gómez) can be traced back to the high seas industrial fishery operating in the South Pacific. Seabirds nesting in the MPAs in the South Pacific are affected by both microplastic ingestion and macroplastic in their nests, but there was no evidence of entangled birds. Conservation of seabirds (and other species) in these oceanic MPAs requires efficient measures to reduce plastic contamination in the ocean. Observations made in the South Pacific coincide with those from other oceanic MPAs, calling for global actions.