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Nonconvex Optimization for 3-Dimensional Point Source Localization Using a Rotating Point Spread Function

Nonconvex optimization for 3-dimensional point source localization using a rotating point spread function
Authors: Chao Wang 0067; Raymond H. Chan; Mila Nikolova; Robert J. Plemmons; Sudhakar Prasad;

Nonconvex Optimization for 3-Dimensional Point Source Localization Using a Rotating Point Spread Function

Abstract

We consider the high-resolution imaging problem of 3D point source image recovery from 2D data using a method based on point spread function (PSF) engineering. The method involves a new technique, recently proposed by S.~Prasad, based on the use of a rotating PSF with a single lobe to obtain depth from defocus. The amount of rotation of the PSF encodes the depth position of the point source. Applications include high-resolution single molecule localization microscopy as well as the problem addressed in this paper on localization of space debris using a space-based telescope. The localization problem is discretized on a cubical lattice where the coordinates of nonzero entries represent the 3D locations and the values of these entries the fluxes of the point sources. Finding the locations and fluxes of the point sources is a large-scale sparse 3D inverse problem. A new nonconvex regularization method with a data-fitting term based on Kullback-Leibler (KL) divergence is proposed for 3D localization for the Poisson noise model. In addition, we propose a new scheme of estimation of the source fluxes from the KL data-fitting term. Numerical experiments illustrate the efficiency and stability of the algorithms that are trained on a random subset of image data before being applied to other images. Our 3D localization algorithms can be readily applied to other kinds of depth-encoding PSFs as well.

28 pages

Keywords

Signal Processing (eess.SP), Nonconvex programming, Nonconvex programming, global optimization, rotation, Numerical mathematical programming methods, FOS: Electrical engineering, electronic engineering, information engineering, image, Electrical Engineering and Systems Science - Signal Processing, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, global optimization, space debris, [MATH.MATH-OC] Mathematics [math]/Optimization and Control [math.OC], image rotation, [MATH.MATH-NA] Mathematics [math]/Numerical Analysis [math.NA], point spread function, image processing, [STAT] Statistics [stat], nonconvex optimization algorithms, Ill-posedness and regularization problems in numerical linear algebra, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], 3D localization, Image processing (compression, reconstruction, etc.) in information and communication theory, 65F22 Ill-posedness & regularization, Optimization and variational techniques

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
11
Top 10%
Average
Top 10%
Green
bronze