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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Diabetes Obesity and...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Diabetes Obesity and Metabolism
Article . 2023 . Peer-reviewed
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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Beneficial effects of automated insulin delivery over one‐year follow‐up in real life for youths and adults with type 1 diabetes irrespective of patient characteristics

Authors: Zoé Henry; Sylvie Villar Fimbel; Nathalie Bendelac; Kevin Perge; Charles Thivolet;

Beneficial effects of automated insulin delivery over one‐year follow‐up in real life for youths and adults with type 1 diabetes irrespective of patient characteristics

Abstract

Abstract Aim To investigate glycaemic outcomes in youths and adults with type 1 diabetes with either MiniMed™ 780G or Tandem t:slim X2™ control‐IQ automated insulin delivery (AID) systems and to evaluate clinical factors that migrate, mitigate the achievement of therapeutic goals. Materials and Methods This retrospective, real‐world, observational study was conducted in a specialized university type 1 diabetes centre with patients observed for 3‐12 months post‐initiation of an AID system. Primary outcomes were the percentage time in the target glucose range [TIR 70‐180 mg/dl (3.9‐10 mmol/L)] as measured by continuous glucose monitoring, mean glucose management indicator (GMI) and glycated haemoglobin (HbA1c) levels. Results Our study cohort consisted of 48 adolescents and 183 adults (55% females) aged 10‐77 years. The mean (95% confidence interval) TIR 70‐180 mg/dl after 30 days was higher than baseline and by 14% points after 360 days with 71.33% (69.4‐73.2) (n = 123, p < .001). HbA1c levels decreased by 0.7% and GMI by 0.6% after 360 days. The proportion of time spent <70 mg/dl (3.9 mmol/L) was not significantly different from baseline. During follow‐up, 780G users had better continuous glucose monitoring results than control‐IQ users but similar HbA1c levels, and an increased risk of weight gain. Age at onset influenced TIR 70‐180 mg/dl in univariate analysis but there was no significant relationship after adjusting on explanatory variables. Baseline body mass index did not influence the performance of AID systems. Conclusions This analysis showed the beneficial effects of two AID systems for people with type 1 diabetes across a broad spectrum of participant characteristics. Only half of the participants achieved international recommendations for glucose control with TIR 70‐180 mg/dl >70%, HbA1c levels or GMI <7%, which outlines the need to maintain strong educational and individual strategies.

Keywords

Adult, Male, Blood Glucose, automated insulin delivery, Adolescent, [SDV]Life Sciences [q-bio], Glucose/therapeutic use, Human/therapeutic use, Hypoglycemic Agents/therapeutic use, Insulin Infusion Systems, Insulin, Regular, Human, Blood Glucose Self-Monitoring/methods, Humans, Insulin, Hypoglycemic Agents, real-world evidence, *Insulin/therapeutic use, Regular, Retrospective Studies, Glycated Hemoglobin, *Diabetes Mellitus, diabetes, Blood Glucose Self-Monitoring, Blood Glucose/analysis, [SDV] Life Sciences [q-bio], Diabetes Mellitus, Type 1, Glucose, time in range, Type 1/drug therapy, Female, closed-loop system, Humans, Male, Female, Adolescent, Adult, Follow-Up Studies, Retrospective Studies, Blood Glucose/analysis, diabetes, *Diabetes Mellitus, Type 1/drug therapy, Hypoglycemic Agents/therapeutic use, Insulin Infusion Systems, Glycated Hemoglobin, automated insulin delivery, closed-loop system, real-world evidence, time in range, *Insulin/therapeutic use, Blood Glucose Self-Monitoring/methods, Glucose/therapeutic use, Insulin, Regular, Human/therapeutic use, Follow-Up Studies

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
24
Top 10%
Top 10%
Top 10%
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