his paper in-depth understands and analyzes the history and current status of the course scheduling at home and abroad, designs a course scheduling system based on genetic algorithms according to the reality needs in the current higher education reform. This algorithm carries out improvement based on the traditional genetic algorithm, can effectively solve the design problems of university course scheduling system algorithm. The experimental results show that this system can well meet the actual needs of current colleges, thus having a certain theoretical meaning and better practical application value.