Complex Qualitative Models in Biology: A New Approach

descriptionPublicationkeyboard_double_arrow_right Article , Preprint 01 Jan 2004Embargo end date: 01 Jan 2006 France English Publisher:S. Karger AGJournal:Complexus, volume 2, pages 140-151 (issn: 1424-8492, eissn: 1424-8506,

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Authors: Veber, Philippe; Le Borgne, Michel; Siegel, Anne; Lagarrigue, Sandrine; Radulescu, Ovidiu;

doi: 10.1159/000093686 , 10.48550/arxiv.q-bio/0604017

arXiv: q-bio/0604017

Complex Qualitative Models in Biology: A New Approach

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Abstract

We advocate the use of qualitative models in the analysis of large biological systems. We show how qualitative models are linked to theoretical differential models and practical graphical models of biological networks. A new technique for analyzing qualitative models is introduced, which is based on an efficient representation of qualitative systems. As shown through several applications, this representation is a relevant tool for the understanding and testing of large and complex biological networks.

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Keywords

[SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Molecular Networks (q-bio.MN), FOS: Biological sciences, Quantitative Biology - Molecular Networks, ACM: J.: Computer Applications/J.3: LIFE AND MEDICAL SCIENCES/J.3.0: Biology and genetics, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], 510, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]

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