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Pulmonary diseases in patients with classical Hodgkin lymphoma relative to a matched background population: A Danish national cohort study

A Danish national cohort study
Authors: Julie Haugaard Vandtved; Andreas Kiesbye Øvlisen; Joachim Baech; Ulla Møller Weinrich; Marianne Tang Severinsen; Eva Futtrup Maksten; Lasse Hjort Jakobsen; +7 Authors

Pulmonary diseases in patients with classical Hodgkin lymphoma relative to a matched background population: A Danish national cohort study

Abstract

SummaryLate toxicities can impact survivorship in patients with classical Hodgkin lymphoma (cHL) with pulmonary toxicity after bleomycin‐containing chemotherapy being a concern. The incidence of pulmonary diseases was examined in this Danish population‐based study. A total of 1474 adult patients with cHL treated with ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) or BEACOPP (bleomycin, vincristine, etoposide, doxorubicin, cyclophosphamide, procarbazine and prednisone) between 2000 and 2018 were included along with 7370 age‐ and sex‐matched comparators from the background population. Median follow‐up was 8.6 years for the patients. Patients with cHL had increased risk of incident pulmonary diseases (HR 2.91 [95% CI 2.30–3.68]), with a 10‐year cumulative risk of 7.4% versus 2.9% for comparators. Excess risks were observed for interstitial lung diseases (HR 15.84 [95% CI 9.35–26.84]) and chronic obstructive pulmonary disease (HR 1.99 [95% CI 1.43–2.76]), with a 10‐year cumulative risk of 4.1% and 3.5% respectively for patients. No excess risk was observed for asthma (HR 0.82 [95% CI 0.43–1.56]). Risk factors for interstitial lung diseases were age ≥60 years, the presence of B‐symptoms and low albumin. These findings document a significant burden of pulmonary diseases among patients with cHL and emphasize the importance of diagnostic work‐up of pulmonary symptoms.

Keywords

Male, Adult, Lung Diseases, hodgkin lymphoma, Vincristine/adverse effects, Adolescent, Respiratory Medicine and Allergy, Denmark, Cyclophosphamide/adverse effects, Cohort Studies, Bleomycin/adverse effects, Bleomycin, Young Adult, Antineoplastic Combined Chemotherapy Protocols, late effects, Humans, obstructive lung diseases, Procarbazine/adverse effects, Cyclophosphamide, Lungmedicin och allergi, Aged, Cancer och onkologi, bleomycin, pulmonary fibrosis, Clinical Laboratory Medicine, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Incidence, Middle Aged, Hodgkin Disease, Denmark/epidemiology, Hodgkin Disease/epidemiology, Klinisk laboratoriemedicin, Lung Diseases/chemically induced, Vincristine, Doxorubicin, Cancer and Oncology, Procarbazine, Female, pulmonary diseases, Doxorubicin/adverse effects

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Top 10%
Average
Average
Green
hybrid
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