Wind turbine blades are normally exposed to significant dynamic loads over their lifetime, including extreme conditions. This can lead to several types of damages such as cracking and delamination. Monitoring the structural condition of the blades to detect damages before they become catastrophic can be important. In recent years, the concept of data-driven structural health monitoring (SHM) approaches for wind turbine blade damage detection has become popular. These methods employ features collected from time series obtained from monitored wind turbine blades to identify damages. However, selecting an optimum number of features, which can reduce computational cost and minimize the effects of environmental and operational conditions, is still a challenge. In this paper, a data-driven approach is developed combining a feature extraction strategy and un-supervised anomaly detection. Monitoring data collected from several accelerometers mounted on a blade of an operating Vestas V27 wind turbine in healthy and damaged scenarios are used in this regard. Several time-domain, temporal, and time-frequency domain features are employed for the purpose of anomaly detection using unsupervised learning methods. Isolation Forest and One-class Support Vector Machine are used to train for anomaly detection. A threshold of detection is established to distinguish between the healthy and damaged states. Results show that the proposed approach can successfully identify the damage cases, but environmental and operational conditions still have some effect when it comes to identifying the extent of the damage.