A field study was carried out during the rabi season 2020-21 to identify weed species and investigate the efficacy of post-emergence herbicides on weeds and their effect on wheat grain yield at AICRP on Wheat, JNKVV, Jabalpur (M.P.). Seven different treatments were applied, namely pinoxaden at 40 g a.i./ha, pinoxaden at 45 g a.i./ha, pinoxaden at 90 g a.i./ha, clodinafop propargyl at 90 g a.i./ha, sulfosulfuron at 25 g a.i./ha as post-emergence (25 DAS), hand weeding at 30 DAS and weedy check. The highest number of individuals was recorded for Medicago denticulata (30.82%), Cichorium intybus (29.94%), Phalaris minor (15.60%), Chenopodium album (15.32%) and Anagallis arvensis (8.30%). All the herbicide treatments provided significant control of weeds causing significant reduction in density of target weed flora and improved the grain yield compared with the weedy check. The highest mortality of weeds (41.12%) was recorded where pinoxaden at 90 g a.i./ha was applied. However, pinoxaden at 45 g a.i./ha is the most effective and best option for higher values of growth parameters, yield attributes and maximum wheat grain yield.