This handbook is a comprehensive and quick guide to the FEDORA project’s findings, insights, and recommendations for science educators, policymakers, and anyone interested in science education as a driver for sustainable futures. It presents a range of perspectives through our studies, a set of recommendations and frameworks, inviting us to apply them in various educational contexts. They are conceived as conceptual tools that can help educators imagine and design future-oriented, engaging, relevant, and meaningful science learning experiences for learners of all ages and backgrounds. Focused on teachers, researchers, policymakers, and interested agents in science education, the FEDORA handbook is a valuable resource that can help us think differently about science education and explore new possibilities for transforming the way we learn, teach, and engage with science and society.