The dataset contains data collected in two-round implementations of teaching modules with Italian secondary school students. The modules concern interdisciplinary topics aimed to develop inter-multi-transdisciplinary skills, imagination or “future-scaffolding” skills (skills that refer to ability to construct visions of the future that empower action in the present with an eye on the horizon). Each implementation lasted between 4 to 50 hours, and different tools (e.g. questionnaires, protocols for focus group and/or individual interviews, classroom video-audio recording, written essays) were used to collect data (before, during and after the implementation). The implementations have been carried out in different contexts (formal, informal) and involved more than 18 students.. The contexts were chosen so as to have a rich and differentiated set of cases, different for age, gender, culture and contexts. In Italy possible contexts for implementation are: classroom contexts of secondary schools (11-19 years of students); afternoon (20h) courses and activities organises in collaborations between universities and schools within established national programs like “Progetto Lauree Scientifiche” (16-19 years of students). Thus, the dataset contains pseudo-anonymised answers to questionnaires, excerpts of written essays, pseudo-anonymized transcripts of the most significant parts of audio/video-recorded individual interviews, focus groups, classroom activities (in the national language). The dataset includes data resulting from the quantitative and qualitative analysis of these materials. The dataset was used for multiple rounds of analysis or by other users interested in investigations on themes and dynamics that characterize teaching/learning processes in science education.