This study was funded by the National Council for Scientific and Technological Development (CNPq)—Brazil (Process number: 150760/2022-1) and the Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil (code 001). F.S.L. was granted a research scholarship (PQ2) from the CNPq (302714/2021-9), BS., LM., CP, and CF are granted a research scholarship from São Paulo Research Foundation (FAPESP)/Brazil (Process Numbers: 2021/11932-8; 2019/25626-6; 2018/23402-0; 2019/26378-6, respectively). M S. was a recipient of donations within the #HCComvida campaign and FAPESP 2020/07765-6. IS was granted a research scholarship from São Paulo Research Foundation (FAPESP)/Brazil (Process Number, 2021/06338-0).

Physical activity status seems to be protective against the severe form of SARS-CoV-2, reducing risk of hospitalization and worsened clinical outcome. However, the impact of physical activity after mild-to-moderate COVID-19 episode on immune and metabolic profiles is unknown. Therefore, this study aimed to evaluate if physical activity is associated with systemic and cellular immunometabolic responses, in young adults after mild-to-moderate COVID-19 infection. Patients previously infected with COVID-19 and healthy controls were recruited for this cross-sectional observational study.